Genomic insights into Wnt signaling in an early diverging metazoan, the ctenophore Mnemiopsis leidyi

Table 1 Wnt/β-catenin pathway members present in the Mnemiopsis leidyi genome

Gene name^a	Mle scaffold or accession number	Pfam domains	E value^b	Human hit^b
WntA	HM448813	Wnt	7e^-46	NP_110388.2: Wnt4
Wnt6	HM448814	Wnt	5e^-48	NP_006513.1: Wnt6
Wnt9	HM448815	Wnt	7e^-59	CAA96283.1: Wnt13
WntX	HM448816	Wnt	4e^-56	NP_110388.2: Wnt4
β-catenin	HM448817	ARM(12)	2e^-109	BAG70078.1: Beta-catenin
Dishevelled (Dsh)	HM448818	DIX, PDZ, DEP	8e^-67	AAB65244.1: DSH3
FrizzledA	HM448819	Fz, Fri 7TM	2e^-89	NP_003498.1: Frizzled7
FrizzledB	HM448820	Fz, Fri 7TM	5e^-34	NP_003498.1: Frizzled7
Sfrp^c	HM448821	Fz	9e^-20	AAD41636.1: Frizzled1
TCF^d	HM448822	HMG	2e^-51	CAB97214: TCF4
Pygopus	HM448823	PHD zinc finger	3e^-17	CAB43209.1: Pygo2
Chibby	HM448824		3e^-6	CAQ07904.1: Chibby1
Porcupine	HM448825	Transmembrane	2e^-24	NP_073736.2: Porc isoA
DIXD^e	HM448826	DIX	9e^-17	AAH41626.2: DIXDC1
LRP5/6^f	c600800006.Contig20	EGF(2), LY, EGF, LY(4), EGF	5e^-27	BA3305.1: LRP5
GSK-3^g	c606000111.Contig2	Ser/Thr kinase	4e^-156	NP_001139628.1: GSK-3 beta
APC^h	c408602200.Contig1	ARM(2)	2e^-17	AAF01784.1: APC2
CK1ⁱ	c608300381.Contig1	Ser/Thr kinase	3e^-127	EAW61775.1: CK1
	c607500101.Contig1	Ser/Thr kinase	9e^-106	CAA56710.1: CK1
Tankyrase	c606800096.Contig3	ANK(10), SAM, PARP, C2	0.0	NP_003738.2: Tankyrase-1
CBP^j	c601400002.Contig7	ZnF, KIX, BROMO, DUF906, ZnF	0.0	AAC51770.1: CREB-binding protein
Groucho/TLE^k	c601900005.Contig5b20	WD40(6), LDLa(3), transmembrane	4e^-108	AAH43247.1: TLE3
Wntless/evi	c607300052.Contig1	transmembrane	1e^-11	BAC11072.1: wntless
Lzic/Icat	c606200080.Contig2		1e^-20	NP_115774: LZIC

^aProvisional gene names and scaffolds of Mnemiopsis Wnt pathway members, along with GenBank Accession numbers of those cloned.
^bAlso listed is the best human BLAST hit with corresponding E value.
^cSfrp = Secreted Frizzled-related;
^dTCF = T-cell-specific transcription factor
^eDIXD = DIX domain containing protein
^fLRP = lipoprotein receptor-related protein
^gGSK-3 = glycogen synthase kinase 3
^hAPC = adenomatous polyposis coli
ⁱCK1 = casein kinase 1
^jCBP = CREB binding protein
^kTLE = transducin-like enhancer of split

ISSN: 2041-9139