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Figure 2 | EvoDevo

Figure 2

From: Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position

Figure 2

shh locus (a) VISTA plot of the shh genomic region ( Latimeria menadoensis shh as reference sequence). Shuffle-LAGAN alignment (repeatmasker applied), visualized with mVISTA. Black peaks indicate conservation of coding sequences. The crossbar indicates the deduced Latimeria shh gene structure (black: exons). Enhancer locations are indicated by grey bars. Repeats are indicated by yellow bars. (b) Overall Conservation of CNE. Histograms present sum lengths of DNA sequence conservation in the shh genomic region from pairwise comparisons within the genomic region from SFPE1/ar-D enhancer to the shh 3' end (for zebrafish-, medaka- and fugu from the putative ar-E enhancer to the shh 3' end). Alignments were established with mLAGAN, conservation parameters for CNE identification were set as: Min Y: 50, min Id: 70, Min length: 60. CNE that mapped shh untranslated regions were excluded from the analysis.

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ISSN: 2041-9139