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Figure 1 | EvoDevo

Figure 1

From: Nuclear receptors from the ctenophore Mnemiopsis leidyi lack a zinc-finger DNA-binding domain: lineage-specific loss or ancestral condition in the emergence of the nuclear receptor superfamily?

Figure 1

Nuclear receptors from the ctenophores Mnemiopsis leidyi and Pleurobrachia pileus. (A) Intron-exon structure of the two nuclear receptors from Mnemiopsis. MlNR2 is a single exon gene. MlNR1 has a more complex intron-exon structure with eight exons, seven of which code for the inferred open-reading frame. (B) Alignment of the amino-terminal region of the ctenophore NRs with the DNA-binding domains of NRs from two sponges (Amphimedon queenslandica (Aq) and Suberites domuncula (Sd)), and HNF4 from Trichoplax adhaerens (Ta), Nematostella vectensis (Nv), Drosophila melanogaster (Dm), and Homo sapiens (Hs). The ctenophore proteins align poorly, including an absence of the conserved cysteines (indicated by black circles), and an optimized alignment contains insertions and deletions relative to the DBD of other animals. (C) Alignment of the ligand-binding domain from the same taxa as in (B). The ctenophore LBD is well-conserved, particularly the nuclear receptor signature motif spanning helix 3 and 4 (boxed).

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EvoDevo

ISSN: 2041-9139