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Figure 2 | EvoDevo

Figure 2

From: Conservation and evolutionary divergence in the activity of receptor-regulated smads

Figure 2

Phenotypes caused by ectopic NvSmad1/5 mRNA mimic phenotypes caused by XSmad1 mRNA. Microinjection of NvSmad1/5 mRNA into the two dorsal blastomeres of a four-cell Xenopus embryo causes similar ventralization phenotypes as injection of XSmad1 mRNA. All tadpoles are shown at stage 34. (A) Shows normal development in Xenopus tadpoles. In contrast, tadpoles in (B) were injected with 4 ng of XSmad1 mRNA and show severe ventralization. (C) Tadpoles injected with 4 ng NvSmad1/5 show a similar but less severe ventralization phenotype. Severity of phenotype was scored according the Dorso-Anterior Index (DAI)[30]. (D) Shows the DAI scores graphically.

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