Figure 3

Phylogenetic tree of Hes/Hey -related genes based on the partial dataset. Partial dataset include all sequences that possess both the basic helix-loop-helix (bHLH) and the Orange domains. The tree topology is obtained from the maximum likelihood (ML) analysis and rooted on Sterol regulatory element binding protein (SREBP) and microphthalmia-associated transcription factor (Mitfa) bHLH genes. A color code was used for node robustness (see inset). Branch and sequence names have specific colors following a color code based on the clade/phylum they belong to (see inset). The letters in front of the nodes refer to Table 2. Dashed lines indicate that branches were artificially reduced for a more aesthetic representation. Hes, Dec, Stich, Helt and Hey family members are highlighted by a specifically colored background.