Figure 2

Selection of genes coexpressed with Mmp2 and Sparc in three vertebrate species. (A) A Venn diagram illustrating the overlap between Mmp2-Sparc coexpressed genes and genes showing expression differences between Arctic charr morphs in a transcriptome profile. Of the 350 genes coexpressed with both Mmp2 and Sparc, 31 genes (yellow) are differentially expressed between the aquaculture (AC) and small benthivorous (SB) morphs. (B) Of the 31 differentially expressed genes, 22 were selected on the basis of craniofacial expression in zebrafish (yellow circles), and their coexpression relationship in three vertebrate species (humans, mice and zebrafish) was depicted using FunCoup. Genes associated with glucocorticoid (GC) signalling were included in the analysis, and four of those (red circles) showed significant connection to the network. The number of connections within the network is shown beside each gene. A cutoff probabilistic confidence value of 0.5 was applied to remove the weak interactions.