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Fig. 3 | EvoDevo

Fig. 3

From: Structure, phylogeny, and expression of the frizzled-related gene family in the lophotrochozoan annelid Platynereis dumerilii

Fig. 3

Conserved structural features of Platynereis Frizzled transmembrane receptors. Multiple alignments of full-length protein sequences for frizzled transmembrane receptors from Platynereis dumerilii (Pd) and Xenopus laevis (Xl) using MAFFT are shown. Gray box N-terminal hydrophobic localization signal. Purple box CRD domain showing conserved Cysteine residues in orange, and NXS/T motif in green. Green box Frizzled transmembrane domain. Purple boxes with asterisks: conserved ‘signature’ residues unique to each frizzled receptor class identified by Schenkelaars et al. (2012) [18], (Fz1/2/7: 1C–G–2C, Fz4: 1C–R–0C, Fz5/8: 3C–R–2C, Fz9/10: 1C–R–2C). Yellow box KTXXXW, PDZ binding motif. Blue box C-terminal ES/TXV motif of Fz1/2/7 and Fz4 homologs

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