Fig. 3

Phylogenetic and structural analyses of He-six3. a Phylogeny of Six family protein sequences. Tree topology resulted from a maximum likelihood analysis. Bootstrap support values are shown above branches (out of 500 bootstrap replicates). Posterior probabilities, based on a Bayesian analysis, are shown below branches. The branch leading to He-Six3 and its name are colored light blue. The names of other H. exemplaris proteins in the tree are colored red. b Structure of the He-six3 gene in the genome. Relative to the sense strand, 5′ is to the left. Thick lines represent exons. Black = UTR. Light blue = sequence that codes for conserved domains. Gray = all other coding sequences. Thin black lines represent introns. The numbers represent nucleotide positions (see Additional file 1: Table S1). c Structure of the He-SIX3 protein. The N-terminus is to the left. Regions that are predicted to be conserved protein domains are colored blue. All other protein sequences are colored gray. The numbers represent amino acid positions (see Additional file 1: Table S1). Dm, Drosophila melanogaster; He, Hypsibius exemplaris; Hs, Homo sapiens