A two-level model for the role of complex and young genes in the formation of organism complexity and new insights into the relationship between evolution and development

Yang, Dong; Xu, Aishi; Shen, Pan; Gao, Chao; Zang, Jiayin; Qiu, Chen; Ouyang, Hongsheng; Jiang, Ying; He, Fuchu

doi:10.1186/s13227-018-0111-4

EvoDevo

Table 1 Results of the spearman correlation analysis for each pair of gene complexity and age factors of mouse

From: A two-level model for the role of complex and young genes in the formation of organism complexity and new insights into the relationship between evolution and development

Factor pairs	M. musculus		G. gallus		D. rerio		D. melanogaster		C. elegans
Factor pairs	R	P	R	P	R	P	R	P	R	P
GL vs. PL	0.58	< 1E−323	0.57	< 1E−323	0.58	< 1E−323	0.79	< 1E−323	0.80	< 1E−323
GL vs. CRMN	0.46	< 1E−323	0.20	2.6E−126	0.04	4.4E−10	0.13	2.5E−50	− 0.12	1.3E−63
GL vs. DNIR	0.33	< 1E−323	0.34	< 1E−323	0.36	< 1E−323	0.42	< 1E−323	0.38	< 1E−323
PL vs. CRMN	0.27	< 1E−323	0.05	2.4E−10	0.01	2.4E−02	0.04	2.2E−07	− 0.09	6.1E−39
PL vs. DNIR	0.52	< 1E−323	0.53	< 1E−323	0.50	< 1E−323	0.48	< 1E−323	0.49	< 1E−323
CRMN vs. DNIR	0.17	3.0E−138	0.01	2.8E−01	0.01	1.7E−01	0.11	3.3E−41	− 0.03	3.9E−05
GOT_Ens vs. GOT_Mode	0.64	< 1E−323	0.47	< 1E−323	0.47	< 1E−323	0.74	< 1E−323	0.64	< 1E−323
GOT_Ens vs. LDT	0.65	< 1E−323	0.52	< 1E−323	0.42	< 1E−323	0.76	< 1E−323	0.87	< 1E−323
GOT_Ens vs. DOT	0.60	< 1E−323	0.51	< 1E−323	0.45	< 1E−323	0.64	< 1E−323	0.67	< 1E−323
GOT_Mode vs. LDT	0.67	< 1E−323	0.37	< 1E−323	0.35	< 1E−323	0.57	< 1E−323	0.50	< 1E−323
GOT_Mode vs. DOT	0.87	< 1E−323	0.39	< 1E−323	0.43	< 1E−323	0.67	< 1E−323	0.60	< 1E−323
LDT vs. DOT	0.40	< 1E−323	0.32	< 1E−323	0.22	2.9E−280	0.48	< 1E−323	0.56	< 1E−323
GL vs. GOT_Ens	− 0.40	< 1E−323	− 0.23	7.9E−175	− 0.30	< 1E−323	− 0.27	1.6E−230	− 0.34	< 1E−323
GL vs. GOT_Mode	− 0.28	< 1E−323	− 0.16	3.3E−83	− 0.17	1.3E−168	− 0.23	8.0E−165	− 0.27	< 1E−323
GL vs. LDT	− 0.44	< 1E−323	− 0.16	4.2E−80	− 0.25	< 1E−323	− 0.29	7.6E−262	− 0.30	< 1E−323
GL vs. DOT	− 0.22	< 1E−323	− 0.06	7.7E−12	− 0.08	2.7E−38	− 0.19	8.0E−115	− 0.32	< 1E−323
PL vs. GOT_Ens	− 0.35	< 1E−323	− 0.25	8.5E−209	− 0.20	2.2E−230	− 0.32	5.6E−321	− 0.41	< 1E−323
PL vs. GOT_Mode	− 0.20	2.0E−175	− 0.14	1.0E−63	− 0.10	2.2E−59	− 0.30	8.3E−278	− 0.32	< 1E−323
PL vs. LDT	− 0.34	< 1E−323	− 0.17	1.6E−97	− 0.13	2.8E−103	− 0.32	< 1E−323	− 0.38	< 1E−323
PL vs. DOT	− 0.21	2.0E−213	− 0.09	1.1E−27	− 0.06	3.4E−23	− 0.23	5.2E−164	− 0.40	< 1E−323
CRMN vs. GOT_Ens	− 0.27	< 1E−323	0.06	1.1E−14	− 0.03	2.3E−06	− 0.13	7.7E−54	0.01	3.4E−01
CRMN vs. GOT_Mode	− 0.13	2.0E−78	− 0.01	4.5E−01	− 0.04	1.7E−09	− 0.10	1.4E−34	− 0.04	7.6E−10
CRMN vs. LDT	− 0.31	< 1E−323	0.04	3.9E−06	− 0.04	6.8E−10	− 0.18	1.1E−106	0.01	5.6E−02
CRMN vs. DOT	− 0.17	< 1E−323	0.04	1.9E−07	− 0.02	6.7E−04	− 0.08	3.5E−19	− 0.01	3.6E−01
DNIR vs. GOT_Ens	− 0.34	< 1E−323	− 0.30	5.6E−302	− 0.25	< 1E−323	− 0.57	< 1E−323	− 0.61	< 1E−323
DNIR vs. GOT_Mode	− 0.20	2.0E−173	− 0.18	5.7E−103	− 0.19	7.1E−207	− 0.50	< 1E−323	− 0.45	< 1E−323
DNIR vs. LDT	− 0.22	6.0E−240	− 0.14	2.2E−68	− 0.10	3.5E−61	− 0.49	< 1E−323	− 0.55	< 1E−323
DNIR vs. DOT	− 0.36	< 1E−323	− 0.31	1.2E−312	− 0.32	< 1E−323	− 0.61	< 1E−323	− 0.79	< 1E−323

The gene complexity factors used in this study included GL (gene length), CRMN (cis-regulatory module number), PL (protein length) and DNIR (domain number including repeats in one protein). The gene age factors included GOT (gene origin time), LDT (last duplication time) and DOT (domain origin time). Correlation coefficients (R) and P values are shown in the table

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ISSN: 2041-9139

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