Fig. 6

Posterior regeneration as a paradigm for studying regenerative mechanisms and their regulation. a Experimental amputation of the posterior part of the body; b key stages (st.1–st.5) of posterior regeneration, re-establishing the growth zone (red), as well as molecular and morphological segment boundaries (dashed lines), reminiscent of the arrangements in posterior growth (right scheme). c Experimental paradigm establishing that transplanted juvenile heads produce a “brain hormone” endowing decerebrated individuals with the capacity to regenerate. d Exemplary results of brain grafts, charting the production of brain hormone (blue) to a medial region of the posterior brain. b Modified after Planques et al. 2019; d modified after Hofmann, 1976