Figure 7
From: Conservation and evolutionary divergence in the activity of receptor-regulated smads
XSmad2ΔExon3 induces expression of downstream Activin/Nodal pathway genes in a pattern resembling XSmad3 rather than full-length XSmad2. Animal caps from gastrulae that had been injected with XSmad2, XSmad2ΔExon3, XSmad3, dSmad2, or NvSmad2 mRNA at the two-cell stage showed elevated expression of genes downstream of the Activin/Nodal pathway. With all markers, the expression patterns induced by XSmad2ΔExon3 (orange column) were more similar to that of XSmad3 (green column) and NvSmad2/3 (teal column) than to full length XSmad2 (red column). (A) Class I marker goosecoid. (B) Class II markers chordin, noggin, and eomesodermin. (C) Class III markers mixer and mix.2.